Resonance Raman Technology
Studies Utilizing Tools Other than the Biophotonic Scanner
The Eye
Bernstein PS, Zhao DY, Sharifzadeh M, Ermakov IV,
Gellermann W. Resonance Raman measurement of macular carotenoids in the living
human eye. Arch Biochem Biophys 2004;15;430(2):163-9.
Bernstein PS, Zhao DY, Wintch SW, Ermakov IV, McClane RW,
Gellermann W. Resonance Raman measurement of macular carotenoids in normal
subjects and in age-related macular degeneration patients. Ophthalmology
2002;109(10):1780-7.
Bernstein, P.S. and Gellermann, W. Measurement of
carotenoids in the living primate eye using resonance Raman spectroscopy. In:
Oxidants and Antioxidants: Ultrastructure and Molecular Biology Protocols, edited
by D. Armstrong, Totowa:Humana Press, Inc., 2002;321-329.
Bernstein, P.S. New insights into the role of the macular
carotenoids in age-related macular degeneration. Resonance Raman studies. Pure
and Applied Chemistry 2002;74(8):1419-1425.
Bernstein PS, Yoshida MD, Katz NB, McClane RW, Gellermann
W. Raman detection of macular carotenoid pigments in intact human retina.
Invest Ophthalmol Vis Sci 1998;39(11):2003-11.
Ermakov IV, Ermakova MR, Gellermann W. Simple Raman
instrument for in vivo detection of macular pigments. Appl Spectrosc
2005;59(7):861-7.
Ermakov I, Ermakova M, Gellermann W, Bernstein PS.
Macular pigment Raman detector for clinical applications. J Biomed Opt 2004;
9(1):139–48.
Ermakov IG, McClane RW, Gellermann W. Resonant Raman
detection of macular pigments in the living human retina. Optics Letters
2001;26(4):202–204.
Gellermann W, Bernstein PS. Noninvasive detection of
macular pigments in the human eye. J Biomed Opt. 2004;9(1):75-85.
Gellermann W, Ermakov IV, Ermakova MR, McClane RW, Zhao DY,
Bernstein PS. In vivo resonant Raman measurement of macular carotenoid pigments
in the young and the aging human retina. J Opt Soc Am A Opt Image Sci Vis.
2002;19(6):1172-86.
Gellermann, W., Ermakov, I,V., McClane, R.W. Raman
imaging of human macular pigments. Optics Letters 2002; 27(1):833–835.
Neelam, K.; O'Gorman, N.; Nolan, J.; O'Donovan, O.; Wong,
H.B.; Au Eong, K.G. and Beatty, S. Measurement of Macular Pigment: Raman
Spectroscopy versus Heterochromatic Flicker Photometry. Invest Ophthalmol Vis
Sci 2005;46(3):1023-1032.
Zhao DY, Wintch SW, Ermakov IV, Gellermann W, Bernstein
PS. Resonance Raman measurement of macular carotenoids in retinal, choroidal,
and macular dystrophies. Arch Ophthalmol 2003;121(7):967-72.
Fruits/Vegetables/Juices
Bhosale P, Ermakov IV, Ermakova MR, Gellermann W,
Bernstein PS. Resonance Raman quantification of nutritionally important
carotenoids in fruits, vegetables, and their juices in comparison to
high-pressure liquid chromatography analysis. J Agric Food Chem 2004;52(11):3281–3285.
The Skin
Ermakov IV, Gellermann W. Validation model for Raman
based skin carotenoid detection. Arch Biochem Biophys 2010;504(1):40-9.
Darvin ME, Patzelt A, Knorr F, Blume-Peytavi U, Sterry W,
Lademann J. One-year study on the variation of carotenoid antioxidant
substances in living human skin: influence of dietary suplementation and stress
factors. J. Biomed. Opt 2008;13(4)(EPub
Ahead of Print Jul/Aug 2008; 044028).
Darwin M, Schanzer S, Teichmann A, Blume-Peytavi U,
Sterry W, Lademann J. [Functional food and bioavailability in the target organ
skin.] Hautarzt. 2006;57(4):286-90. German.
Ermakov IV, Ermakova MR, Gellermann W, Lademann J.
Noninvasive selective detection of lycopene and beta-carotene in human skin
using Raman spectroscopy. J Biomed Opt 2004;9(2):332–8.
Ermakov et al. Resonance Raman detection of carotenoid
antioxidants in living human tissues. Optics Letters 2001;26(15):1179–1181.
Gellermann, W., Ermakov, I.V., Scholz, T.A. and
Bernstein, P. S. Noninvasive laser Raman detection of carotenoid antioxidants
in skin. Cosmetic Dermatology 2002;15(9):65-68.
Hata TR, Scholz TA, Ermakov IV, McClane RW, Khachik F,
Gellermann W, Pershing LK. Non-invasive Raman spectroscopic detection of
carotenoids in human skin. J Invest Dermatology 2000;115:441-448.
Studies Utilizing
the Pharmanex Biophotonic Scanner
Abstracts
Wengreen H, Aguilar S, Lefevre M. Skin Carotenoids as a
Biomarker of Fruit and Vegetable Intake in Children. Presented at American
Dietetic Association’s Food & Nutrition Conference & Expo. Boston,Ma.
November 6-9, 2010.
Bi, S.X., Li, C.L., Guo, H.W., Poole, S., Zhu, J. S. The
effects of life styles and LifePak on human skin carotenoids scores measured by
resonance Raman spectroscopy BioPhotonic Scanner. FASEB Journal 2007;21(4):A709.
Changling Li, Hongwei Guo, Senxu Bi, Zhu, Z.G., Zhu, J.
S. Skin Carotenoids Measured by Resonance Raman Spectroscopy BioPhotonic
Scanner and the Effects of Life Styles and LifePak on Human Carotenoids
Nutritional Status and Skin Scores.
Asian Pacific Journal of Clinical Nutrition 2006;15(Suppl.):S79.
Zukley, LM., Nguyen,V, Lowndes, J., Smidt, C.,
Angelopoulos, TJ., Rippe, JM., Effects of antioxidant supplementation on skin
and serum carotenoids, FASEB Journal 2006;20:A145.
Fiutem J, Zukley L, Geise T, Legowski P, Nguyen V, Dube
T, Yount B, Smidt C, Angelopoulos T, Rippe J. Adiposity Negatively Influences
Carotenoids and Antioxidant Status in Overweight Individuals. Medicine and
Science in Sports and Exercise Suppl 2004;36(5):A302.
Smidt, C. R.; W. R. Gellermann and J. R. Zidichouski.
Noninvasive Raman spectroscopy measurement of human carotenoid status. FASEB
Journal 2004;18(4):A480.
Smidt, C.R., Shieh, D. Non-invasive, biophotonic
assessment of skin carotenoids as a biomarker of human antioxidant status.
FASEB Journal 2003;17(5):A1115.
Zukley L, Legowski P, Nguyen V, Geise T, Lowndes J,
Melanson K, Angelopoulos T, Rippe J. The Effect of Weight Loss on Dietary
Carotenoid and Skin Carotenoid Levels in Subjects Participating in a Weight
Loss Study. Obesity Research Suppl 2004;12:A57.
Full-Length Articles Published in Peer Reviewed Journals
Lima X, Kimball A. Skin Carotenoid Levels in Adult
Patients with Psoriasis. J Eur Acad Dermatol Venereol. Nov 4, 2010.
Bergeson SD, Peatross JB, Eyring NJ, Fralick JF,
Stevenson DN, Ferguson SB. Resonance Raman measurements of carotenoids using
light-emitting diodes. J. Biomed. Opt 2008;13(EPub Ahead of Print Jul. 15,
2008; 044026).
Rerksuppaphol S, Rerksuppaphol L. Effect of fruit and
vegetable intake on skin carotenoid detected by non-invasive Raman
spectroscopy. J Med Assoc Thai 2006;89(8):1206-12.
Li CL, Bi SX, Zhu JS, Zhu ZG. New functions of
carotenoids and clinical assessments. Shanghai Journal of Preventive Medicine
2006;6:261-264.
Guo HW, Li H, Huang ZY, Xue K, Zhou X, Ma YY, Liu M, Zhu
ZG, Li CL, Zhu JS. Examination of Carotenoids in Human Skin by Biophotonic
Raman Spectroscopy Scanner. Journal of Environmental and Occupational Medicine
2006;23(3):204-206.
Li CL, Bi SX, Poole S, Smidt C, Zhu JS. Human Skin Carotenoids in 88,611 subjects
measured by Biophotonic Scanner. Chinese Journal of Clinical Pharmacy
2006;15(2):124-125.
Smidt, C.R. Non-invasive Raman spectroscopic detection of
carotenoids in human skin as a biomarker of antioxidant status. J. Korean Acad
Fam Med 2005;26(4):S398-408.
Smidt, C.R., Burke, D.S. Nutritional significance and
measurement of carotenoids. Current Topics in Nutraceutical Research
2004;2(2):79-91.
Book Chapters/Book Segments
Gellermann W, Zidichouski JA, Smidt CR, Bernstein PS. Raman
Detection of Carotenoids in Human Tissue. In: Packer L, Obermueller‑Jevic
U, Kraemer K, and Sies H, eds. Carotenoids and Retinoids – Molecular Aspects and Health
Issues. Champaign, IL: AOCS Press, 2005; Ch. 6, 86‑114.
Mahan LK and Escott-Stump S. (Eds.). Krause's Food,
Nutrition and Diet Therapy, 12th Ed. Philadelphia, PA: Saunders 2007; Ch. 15,
427-428.